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Phase 1b (2021) Enebo and colleagues published a randomized, placebo-controlled, multiple-ascending-dose Phase 1b trial in The Lancet in 2021 [3]

doi: 10.1002/cam4.6619 52 LeeHTKimYParkUBJeongTJLeeSHHeoY-S

Studies in melanocyte cell lines and receptor-transfected systems have characterised the cAMP signalling response, tyrosinase induction, and melanin output associated with MT-1 receptor engagement