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Utilizing an unsupervised ML approach by k-means clustering on biomarkers, without histological endpoints or treatment, subjects were categorized into 3 distinct groups: high (Group 1), moderate (Group 2) and low (Group 3) responders

This is the only pathway for the biosynthesis of the amino acid Cys

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Future research should prioritize: a) Standardizing resistance definitions across models to allow for more reproducible studies

Downie D, McFadyen MC, Rooney PH, Cruickshank ME, Parkin DE, Miller ID, et al

Further, this observation thus highlights that unconventional antigen presentation on non-hematopoietic ECs via HLA class 1, in addition to conventional antigen presentation by professional APCs (monocyte, DC, and macrophage), can be considered as a potential target for therapeutic development