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Mutations in FXN lead to impaired ironsulfur cluster formation, triggering intracellular iron starvation responses that paradoxically result in mitochondrial iron overload, oxidative stress, and subsequent cellular dysfunction (386)

These observations also highlight that therapeutic approaches should be directed at specific aspects of astrocyte reactivity, for example astrocyte Ccl2 production, rather than at attenuating reactivity per se, which may lead to unexpected and undesirable consequences

Acta Haematol 108:1922

then apply a cream, and in the morning be sure to apply broad-spectrum SPF protection

Natural killer cells in immunodefense against infective agents

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