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a) Loperamide (Imodium) OTC, most commonly used Acts on -opioid receptors in gut Does not cross BBB no CNS effects b) Diphenoxylate + Atropine (Lomotil) Diphenoxylate slows motility Atropine added to prevent abuse High doses CNS effects Uses: Non-infectious diarrhea (e.g., IBS, travelers diarrhea) Avoid in: Bloody diarrhea, C

Any use should be framed as investigational with appropriate informed consent and outcome tracking

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