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Oral Multi-Receptor Agonists The next frontier beyond oral GLP-1 monotherapy is oral multi-receptor agonism

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The predicted inhibitor-binding mode of 1j with an orientation and conformation that favors most negative docking score when superimposed with the endogenous substrate NCA of the NNMT enzyme indicated that the analog binds consistent with the binding mode of NCA, i.e., the N1-atom of both ligands aligned almost identical, conferring similar molecular interactions with key residues within the active site of the enzyme

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Clinical effect depends on the reason for use, individual metabolism, formulation, and adherence, so a clinician sets the cadence after reviewing your history and goals rather than following a blanket interval from an article