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These results validated that ZZW-115 worked efficiently in blocking the nuclear translocation of NUPR1 in our culture model and that inhibition of NUPR1 nuclear translocation induces cell death in phBECs, indicating an important protective role in bronchial epithelial cells

When this chemical is injected directly into the body, it distributes uniformly throughout the body

tabaci , in a persistent-circulative manner

and (2) pharmacodynamic effects may derive from short-lived parent species acting locally (e.g., in the gut or at mucosal surfaces) or from active metabolites

Furthermore, recent studies identify the involvement of a kidneybrain axis, wherein renal dysfunction may exacerbate neurodegeneration through impaired clearance of neurotoxic metabolites, chronic systemic inflammation, and metabolic dysregulation [32, 33, 34]