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Ferroptosis suppressor protein 1 (FSP1), originally identified as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), was rediscovered through unbiased genetic screens as a potent GPX4-independent ferroptosis inhibitor (96)

DZN also induces oxidative stress in rat hepatocytes and damages renal function by decreasing renal glutathione and producing antioxidant enzymes [9, 10]

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Notably, patients who exhibited significant increases in the autophagy marker LC3-II in PBMCs showed better survival outcomes, suggesting that stronger autophagy inhibition may provide greater benefit [99, 102]

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doi: 10.1007/s10142-023-01055-7