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Chronic sleep deprivation (consistently less than 7 hours or poor-quality sleep) accelerates every hallmark of aging: increased inflammation, impaired glucose metabolism, reduced growth hormone production, accelerated cognitive decline, weakened immune function, and increased cortisol

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Although the increased yield of adenosine triphosphate (ATP), a common form of cellular energy currency, was metabolically beneficial, the tradeoff between efficiency and risk to the metabolic machinery grew more prominent

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J Comp Neurol 131:143154 Hochstim C, Deneen B, Lukaszewicz A et al (2008) Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code