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Oncometabolites-driven tumorigenesis: From genetics to targeted therapy

Allometric scaling: Using the FDA's standard body surface area conversion (rat dose x 0.162), the human equivalent range is roughly 110-560 mcg/day -- which is where the community's 250-500 mcg/day window comes from

Pooled HCAEC lysates from 4 donors (1 mg protein/mL) were incubated with 05 mM MGO for 1 h in PBS, with the formation of AGE determined by ELISA after cell lysis: (A) hydroimidazolones

This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for human consumption, self-experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.

As a result, we are seeing a significant rise in the number and variety of childhood allergies, cancers, juvenile diabetes, and chronic infections