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The disruption of the intestinal flora can also lead to increased permeability of the blood-brain barrier, with potential adverse effects on brain health ( via the vagus nerve and alter the production of tryptophan, the precursor of serotonin ( A systematic review and meta-analysis of 59 case-control studies identified a transdiagnostic pattern of gut microbiota perturbations across psychiatric disorders, including depression, bipolar disorder, schizophrenia, and anxiety

Xu et al., 2012

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Or that it can cause poor digestion and even feed harmful bacteria

11A) and DHLA@AuNPs (Fig

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