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In CRC, the reactivation or remodeling of mitochondrial metabolic pathways, particularly oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO), is closely associated with key oncogenic processes such as the evasion of apoptosis, the maintenance of cancer stem cell properties, and the regulation of redox homeostasis [5,6,7,8]

Crit Rev Biotechnol 39:181191 Jdrejko KJ, Lazur J, Muszyska B (2021) Cordyceps militaris : an overview of its chemical constituents in relation to biological activity

These nanoparticles demonstrated superior biocompatibility, reactive oxygen species reactivity, and the capacity to escape macrophage clearance while specifically targeting inflamed endothelium cells

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Polyphenols exert their effects by targeting multiple pathways implicated in PD, including neuroinflammation, oxidative stress (reactive oxygen species, ROS), and protein aggregation, thereby potentially protecting vulnerable neurons (12) (Figure 1)