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The critical design choice was the C-terminal PGP extension: Pro-Gly-Pro provides primary resistance to proteolytic degradation, extending the compound's half-life from the minutes range of native ACTH(4-7) to approximately several hours, enabling meaningful and sustained CNS activity following administration

Baig MH, Ahmad K, Rabbani G, Choi I (2018) Use of peptides for the management of Alzheimers disease: diagnosis and inhibition

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Like ASXL1, the transcriptional co-activator bromodomain and extra-terminal domain 4 (BRD4) is also linked to tumorigenesis

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