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39 EisenbergT.SchroederS.AndryushkovaA.PendlT.KttnerV.BhukelA.et al (2014)

Combining hypoxic methods for peak performance

and Gyarmati et al

Bi-directional transport of MeHg across monolayers of MDCKII-MRP1 and MDCKII-parental cells MDCKII-MRP1 and MDCKII-parental cells were seeded on microporous polycarbonate mem-brane inserts (Costar

The research indicates that the absence of NOL1/NOP2/Sun domain family, member 5 (NSUN5) leads to a reduction in the levels of 5-methylcytosine in ferritin heavy chain 1(FTH1)/ferritin light chain (FTL) RNA, which results in increased iron concentration in BMSCs, downregulation of GPX4, and accumulation of ROS and lipid peroxidation products ( 2.3.3 Cellular metabolism and survival regulation pathways The PI3K/AKT/mTOR pathway, as a classic pro-survival pathway, is involved in the maintenance of bone homeostasis

Whilst promising preclinical examples like trastuzumab-Pt(II) and cetuximab-C8Pt(IV) bring optimism to combinatorial approaches, significant challenges including stability and controlled payload release remain to be addressed before clinical translation