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Collectively, these changes contribute to oxidative DNA damage, lipid peroxidation, and follicular apoptosis (Trujillo et al

MG-induced DNA damage plays a central role in initiating apoptosis.MG induces DNA strand breaks through the formation of adducts (e.g., MGdG) and cross-linking structures with DNA, activating the intracellular DNA damage response, and triggering apoptosis by cell cycle arrest when the damage exceeds the cellular ability to repair it (104)

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The Lancet Respiratory Medicine (2020)

The results suggested that the upregulation of miR-153-3p alleviated the reduction in cell viability caused by 6-OHDA and reduced the secretion of lactate dehydrogenase (LDH)

We just have to find the root cause