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For hepatitis B and C, Sofosbuvir, an oral drug approved by the FDA in 2013, have been shown to be a substrate of P-gp and BCRP
DTP cells maintain their drug-resistant phenotype through dynamic epigenetic modifications
the ability of a compound to inhibit tumor growth may be evaluated in an animal model predictive of efficacy the pharmaceutical composition can be administered as a sole therapeutic or in combination with additional therapies such as anti-cancer therapies as needed, e.g
FIGURE 1 1.2.1 FBS non-conformities and quality variation Cellular heterogeneity in response to exogenous stimuli complicates the determination of whether observed differences in cell behaviour arise from the experimental variables under investigation or from unintended influences of the culture environment (Czapla et al., 2019)
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