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Its especially important for producing nitric oxide, which widens blood vessels to support blood flow, promoting immune function and aiding cellular communication

doi: 10.1007/s00484-014-0829-1 73

Those exceptional Qualifying variants most likely to be disease related were categorized as Key Qualifying variants, and additionally met at least one of the following categories: Pathogenic or Likely Pathogenic (P/LP) variants: These variants are listed in ClinVar 6 as being either pathogenic (P) or likely pathogenic (LP) for disease

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