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The synthesis in extrapineal sites presumably does not follow circadian rhythms, except for the retina, and mainly works as a local antioxidant 15,16

Advanced Research Science

10.1016/j.phytochem.2009.07.036 4 AngelinoD.DoszE

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Lorente-Cantarero, F.J

Acknowledgements We thank Yale School Medicine, Yale West Campus, Systems Biology Institute and Cancer Biology Institute for the instrumentation supports