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Although comorbid anxiety and depression are both clinically common and worrisome, the mechanisms of comorbidity are poorly understood

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M1 macrophages exhibit bactericidal, pro-inflammatory, and anti-tumor functions, whereas M2 macrophages are primarily involved in tissue repair and anti-inflammatory processes and pro-tumor activities 88

Brit J Pharmacol 174(12):15331554 Le TN, Schumann U, Smith NA, Tiwari S, Au PCK, Zhu QH, Taylor JM, Kazan K, Llewellyn DJ, Zhang R (2014) DNA demethylases target promoter transposable elements to positively regulate stress responsive genes in Arabidopsis

36,37 Zonula occludens (ZO), including ZO-1 and its homologs ZO-2 and ZO-3, is a group of PDZ-related scaffolding proteins that belong to the superfamily of membrane-associated guanylate kinase-like proteins, possessing sites of three tandem PDZ domains at the N-terminus 38,39 (Figure 1)

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