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Treatment with belimumab restores B cell subsets and their expression of B cell activating factor receptor in patients with primary Sjogrens syndrome

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96 In addition, glomerulations may be seen in patients who have undergone radiation therapy, in the presence of active bladder carcinoma, associated with chemotherapeutic or toxic drug exposure, and in patients with defunctionalized bladders, and in patients without any urologic symptoms

older roots contain lower levels of saponins, with annual roots offering the highest quality (Teng et al., 2009)