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Other related diseases such as fontal temporal dementia (FTD) appears to have overlap both with AD and ALS, and is commonly related with TDP-43 and C9ORF72 mutations of ALS (Warren et al., 2013), although there is evidence for TDP-43 involvement in AD, it appears to take a different progression pattern compared to ALS and FTD (Meneses et al., 2021), which suggests distinct disease mechanisms at play

doi: 10.3390/ijms26031098 90 ShuWHYangSHWeiMLiuXCChenZXWeiCYet al

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Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing