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Moreover, cytosolic GSTs, which are typically 200-250 amino acids in length, form homo- or hetero-dimers, whereas microsomal GSTs are smaller (nearly 150 amino acids) and form trimers [62, 66]

Bowden, J., Davey Smith, G., Haycock, P

These stimuli will also stimulate brain microglia and trigger the NLRP3 inflammasome to release IL-1 and IL-18 (Troubat et al., 2021)

In summary, our data suggest that relative to healthy tissue, tumors experience more intracellular oxidative stress, triggering intracellular antioxidative support