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When mitochondria underperform, cells have trouble making enough ATP, the bodys energy currency

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Munoz M, Villar I, Garcia-Erce JA

However, free iron in mitochondria and the cytoplasm can generate highly oxidative HO, which damages polyunsaturated fatty acids (PUFAs) in the phospholipid bilayer, leading to mitochondrial outer membrane permeabilization (MOMP), ultimately abrogating DNA stability and inducing cell death