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Navarro-Hortal MD, Romero-Mrquez JM, Esteban-Muoz A, Snchez-Gonzlez C, Rivas-Garca L, Llopis J, Cianciosi D, Giampieri F, Sumalla-Cano S, Battino M, Quiles JL (2022) Strawberry ( Fragaria ananassa cv

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BD patients show high rates of concomitant morbidity and mortality, with 10-20 years less life expectancy than the general population [6]

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Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts