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Strengthens bones and prevents rickets

Kernicterus mechanism: When unconjugated bilirubin exceeds albumin-binding capacity (high bilirubin levels, low albumin, acidosis, or displacing drugs), free bilirubin crosses the BBB and deposits in the basal ganglia (globus pallidus, subthalamic nucleus), cerebellum, and hippocampus, causing oxidative damage and neuronal death

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Zanr V, Campagnari R, Cerulli A, Masullo M, Cardile A, Piacente S, et al

A recent FDA 503A update in the U.S

71.3% achieved mRS2 or baseline at 3 months with IVT vs