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Future efforts must therefore harness structural and chemical biology to create highly selective agonists/antagonists that discriminate lactylation from other modifications, especially acetylation

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doi: 10.3389/fendo.2023.1211473 143 SmithTJ

This equilibrium is particularly critical in high-energy-demand tissues, such as the heart, where copper serves as an indispensable cofactor for key metabolic enzymes and mitochondrial function [18, 19]

HNMT is a cytosolic enzyme expressed widely across the body (kidneys, liver, brain, respiratory tract, skin) and is responsible for breaking down histamine within cells