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PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8(+) T lymphocytes

doi: 10.1038/nri3399 192 ChangYSyahirahRWangXJinGTorregrosa-AllenSElzeyBDet al

The majority of patients with persistent viral antigens reported sequelae of COVID-19, which indicated viral antigen persistence may be the basics of PACS (Zollner et al., 2022)

B., Gottlieb, S

& Gertler, F

A model that describes this concept is the cell danger response, a protective mechanism that slows down cellular metabolism and energy production when the cell senses a threat, such as an infection or toxin, to prevent further damage