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The Kyn-AhR axis additionally polarizes macrophages toward M2 phenotypes and expands Treg populations (291), while AhR blockade in AOM/DSS models reverses TAM polarization, suppresses Tregs, and enhances CD8 + T cell infiltration to ameliorate colitis-associated carcinogenesis (292)

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3.2.10 Polymeric nanoparticles By encapsulating multiple neuroprotective agents, polymeric nanoparticles can modulate immune responses and even promote neuronal regeneration by providing multifunctional therapeutic benefits