Nos: 5,863,538,5,855,907,5,855,866,5,780,592,5,776,427,5,651,987,5,346,887,5,256,408,5,252,319,5,209,926,4,996,335,4,927,807,4,910,192,4,710,495,4,049,805,4,004,005,3,670,079,3,608,076,5,892,028,5,888,995,5,883,087,5,880,115,5,869,475,5,866,558,5,861,390,5,861,388,5,854,235,5,837,698,5,834,452,5,830,886,5,792,758,5,792,757,5,763,361,5,744,462,5,741,787,5,741,786,5,733,899,5,731,345,5,723,638,5,721,226,5,712,264,5,712,263,5,710,144,5,707,984,5,705,494,5,700,793,5,698,720,5,698,545,5,696,106,5,677,293,5,674,861,5,661,141,5,656,621,5,646,136,5,637,691,5,616,574,5,614,514,5,604,215,5,604,213,5,599,807,5,585,482,5,565,588,5,563,259,5,563,131,5,561,124,5,556,845,5,547,949,5,536,714,5,527,806,5,506,354,5,506,221,5,494,907,5,491,136,5,478,956,5,426,179,5,422,262,5,391,776,5,382,661,5,380,841,5,380,840,5,380,839,5,373,095,5,371,078,5,352,809,5,344,827,5,344,826,5,338,837,5,336,686,5,292,906,5,292,878,5,281,587,5,272,140,5,244,886,5,236,912,5,232,915,5,219,879,5,218,109,5,215,972,5,212,166,5,206,415,5,194,602,5,166,201,5,166,055,5,126,488,5,116,829,5,108,996,5,099,037,5,096,892,5,093,502,5,086,047,5,084,450,5,082,835,5,081,114,5,053,404,5,041,433,5,041,432,5,034,548,5,032,586,5,026,882,4,996,335,4,975,537,4,970,205,4,954,446,4,950,428,4,946,834,4,937,237,4,921,846,4,920,099,4,910,226,4,900,725,4,892,867,4,888,336,4,885,280,4,882,322,4,882,319,4,882,315,4,874,855,4,868,167,4,865,767,4,861,875,4,861,765,4,861,763,4,847,014,4,774,236,4,753,932,4,711,856,4,710,495,4,701,450,4,701,449,4,689,410,4,680,290,4,670,551,4,664,850,4,659,516,4,647,410,4,634,695,4,634,693,4,588,530,4,567,000,4,560,557,4,558,041,4,552,871,4,552,868,4,541,956,4,519,946,4,515,787,4,512,986,4,502,989,4,495,102

The pattern also coincides with the report of Dubey et al
Data sources for all outcomes have listed in Additional file 1: Table S1
[DOI] [PubMed] [Google Scholar] 101.Kim J.Y., Min J.Y., Baek J.M., Ahn S.J., Jun H.Y., Yoon K.H., Choi M.K., Lee M.S., Oh J
They are also involved in the inception and pathogenesis of several chronic diseases including neurodegenerative disorders, diabetes, aging processes, arthritis, cardiovascular impairment, chronic inflammation, and hepatic disorders 33
Giblin K, Kaplan LM, Somers VK, et al