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The separate antibiotic research of THH and JFG shows that their efficacy has decreased significantly after the microbiota is removed, which shows that their anti-rheumatic effect depends on the microbiota and gives a necessity signal (Zheng et al., 2023

Sakurauchi, Y., Matsumoto, Y., Shinzato, T., Takai, I., Nakamura, Y., Sato, M., Nakai, S., Miwa, M., Morita, H., Miwa, T., Amano, I., and Maeda, K

doi: 10.1007/s00394-023-03089-w 97

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5HT1A receptors are known to negatively regulate serotonin neurons and are expressed as presynaptic autoreceptors in the raphe nucleus and postsynaptic receptors on cortical, hippocampus, hypothalamic and spinal regions, implicated in emotion, mood, motor activity, and stress responses (Drevets et al