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7.1.1.1 Monoclonal antibodies Antibodies targeting specific cytokines, such as TNF- inhibitors (e.g., infliximab and adalimumab), have been shown to decrease the levels of systemic inflammation and reduce BBB dysfunction (Esposito and Cuzzocrea, 2009)

Int J Mol Med 41(3):14771486 Rai SN (2021) Recent advances in the treatment of neurodegenerative disorders

Oral acetylcysteine administration has resulted in minimal anaphylactoid reactions and is safer than i.v

Acute inflammation is needed to remove the damaging agents and the injured tissues, thereby promoting tissue repair

57 Overall, the sirtuin family acts as a critical regulator of immune aging by fine-tuning metabolic and inflammatory pathways in multiple immune cell types