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This work is supported by the National Natural Science Foundation of China (Nos

Conclusion: CTSD may be a possible biomarker of severe NAFLD since its hepatic/adipose tissue expression as well as circulating levels correlated with liver damage thus allowing to discriminate advanced disease

Vegetables in the brassica family produce the most glutathione, but the molecule is present in large amounts in several other vegetables

Similarly, metabolomic profiling of blood and CSF in patients, alongside microbiome data, can identify which microbial metabolites truly cross into the brain and affect pathways like amyloid deposition or axonal integrity

Patients with chronic kidney disease, dialysis needs, or advanced liver conditions should only consider IV infusion under close medical supervision

Methods This research complies all relevant ethical regulations