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Cell culture and plasmid transfection HEK-293T cells were purchased from ATCC (Cat #CRL-3216)

Skin Aging and Collagen Loss Skin aging involves several structural changes: reduced collagen synthesis increased collagen degradation decreased elastin integrity slower cellular turnover These processes contribute to wrinkles, skin laxity, and reduced resilience

Furthermore, uptake into cells was dependent on protein uptake rates, therefore increased uptake was achieved in BSA-medium (~ 26%) in contrast to only ~ 17% uptake in serum-medium (Barrouillet et al

WT FUS also activates NF-B, the master regulator of inflammation, and induces expression of both pro-inflammatory markers and redox signaling proteins in microglia (Frakes et al., 2014

We encourage you to properly dispose of it according to local waste management guidelines