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Joint tissues contain estrogen receptors, meaning estrogen directly influences how collagen is produced and how joint tissues are maintained and repaired

No published peer-reviewed human clinical trials of Dihexa exist as of 2025

doi: 10.3109/13685538.2012.729233 36 SnyderPJBhasinSCunninghamGRMatsumotoAMStephens-ShieldsAJCauleyJAet al

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