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Nat Rev Endocrinol 13:161

Externally introduced arginase analogs can inhibit T cells antitumor activity by reducing the arginine level in the tumor microenvironment, just as the tumor or immunosuppressive cells expressing arginase 1 can

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Depleted GSH worked together with the glutaminase inhibitor to relieve oxaliplatin efflux, resulting in remarkable anticancer efficiency in tumor cells and tissue (Figures 4E, F)

Malhotra et al., 2010

GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig