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This pharmaceutical composition comprises a pharmaceutically acceptable carrier or diluent and a compound according to formula (I): R 1 and R 2 , are independently selected from the group consisting of no atom, H, D, O, halo, C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkyl-heteroaryl, C 1-6 alkenyl, C 1-6 alkenyl-aryl, and C 1-6 alkenyl-heteroaryl, wherein the C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkyl-heteroaryl, C 1-6 alkenyl, C 1-6 alkenyl-aryl, and C 1-6 alkenyl-heteroaryl may be optionally substituted with an atom or a group selected from the group consisting of halo, deuterium, C 1-4 alkyl, CF 3 , and combinations thereof

HIF1, hypoxia-inducible factor-1

A., Zinelis, P

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8 About half of the reported patients presented early (3 months to 2.5 years) with metabolic decompensation characterized by episodes of hypoketotic hypoglycemia, hyperammonemia, hepatomegaly, elevated transaminases, and hepatic encephalopathy

Methods Enzymol 77:5059 Prabakaran D, Ashokkumar N (2013) Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats