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J Clin Invest (2003) 112:40714

This process involves the activation of a cascade of caspase enzymes, particularly caspase-3, which executing apoptosis through the cleavage of key intracellular substrates

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Telaglenastat Plus Cabozantinib or Everolimus For Advanced or Metastatic Renal Cell Carcinoma: an Open-Label Phase 1 Trial