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2a), while the peak at 2.823.01 ppm was attributed to the methylene protons adjacent to the imine group (-CH 2 -) (Fig

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10.1016/j.cellimm.2011.07.015 105

FFAs also activate the IKK- and JNK pathways, further exacerbating IR via PKC- activation (60)

However, contrary to the original hypothesis put forward by Rubenstein and Merzenich 5 that ASD might be rooted in increased cortical excitability, our data on humans, as well as ours and recent work 24 on several rodent models of ASD, are suggestive of a region-specific imbalance slanted toward reduced excitation

As a lipid soluble analogue of thiamine, benfotiamine has been extensively studied in the context of diabetic complications