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This guide is written for both laboratory scientists and research professionals who need a thorough scientific reference, and for scientifically curious individuals who want to understand the biochemistry behind this compound and why it continues to generate active research interest

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A high activity was encountered, Ki = 5.1 nM, to be compared with 23 (HA08) with a Ki of 3.3 nM, the latter comprising a 13-membered macrocyclic system

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