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Other studies further support the beneficial effects of radiotherapy following mastectomy and adjuvant chemotherapy, even in high-risk cases with lymph node involvement, large tumors, compromised surgical margins, or in the presence of multiple risk factors such as age 50 years, triple-negative tumors, high tumor grade, and lymphovascular invasion 52,53

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MITOCHONDRIA AS A SIGNAL INTEGRATION PLATFORM IN APAP HEPATOTOXICITY In addition to being a source of free radicals which initiate signaling events, the mitochondria also act as signal-integrating platforms, where cytosolic proteins are translocated to amplify damage induced by the initial oxidative stress

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