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410 The MEK inhibitor PD98059 suppresses ROS-induced ERK1/2 activation, reducing glial fibrillary acidic protein (GFAP) expression (a marker of gliosis)

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10.1007/s00213-018-4992-7 39

Mol Cancer Ther 2014;13:890901

Briefly, the autoinflammatory paradigm highlights inflammation as the primary HS disease driver, with subclinical inflammation developing due to disparate contributing factors on a background of topographic predisposition (55)