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NAD + is also involved in nucleotide and amino acid synthesis, such as the folate-dependent serine catabolism 347 , as well as genomic DNA replication, as reviewed above 118

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APR-017 treatment led to increased ROS level and decreased GSH level in PDCs with low expression of VRK2 rather than PDCs with high expression of VRK2 (Fig

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It inhibited the expression of cyclin D3, leading to the arrest of the cell cycle in the G1/S phase

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