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In addition, some of them and new complex I inhibitors have been used in clinical trials as antitumoral agents, such as metformin (in colorectal, breast and prostate cancer), IACS-010759 (in acute myeloid leukemia and certain solid tumors), IM156 (in gastric, colorectal and ovarian cancer) and MitoTam (in renal cell carcinoma) (6265)

It can also lead to muscle loss, weight gain, increased belly fat, and an elevated risk of osteoporosis, further stressing joints

They also noted that the benefits of oral corticosteroid treatment may not persist beyond one year and could increase the risk of adverse effects

Anatomic and histologic study of variations in the deltoid ligament of the ankle

Cells 8, 1436

Zhu AK, Shan YQ, Zhang J, Liu XC, Ying RC, Kong WC (2021) Exosomal NNMT from peritoneum lavage fluid promotes peritoneal metastasis in gastric cancer