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In addition, many of the lifestyle interventions helpful for Hashimotos are also beneficial for the MTHFR variation

1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase

10.1016/j.atherosclerosis.2014.09.028 [DOI] [PubMed] [Google Scholar] 93.Vasan RS

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