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The hydroxyl radical can react with multiple components of the cell, leading to their dysfunction

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Chem Res Toxicol 21:213447 Siems W, Crifo C, Capuozzo E, Uchida K, Grune T, Salerno C (2010) Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes

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Our study revealed that antioxidant supplementation was effective in patients with high oxidative stress level, suggesting that such supplementation may be a novel way of combating diseases induced by systemic oxidative stress, and could contribute to individualized treatment for these diseases