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In addition, ERK1/2 plays a critical role in regulation of the polyphenol chlorogenic acid-derived Nrf2 transcriptional activation

Medicine & Science in Sports & Exercise

doi: 108

Conforms to USP for weight

In the absence of a target, structure-activity work is constrained to behavioral and EEG endpoints, which are too noisy and too downstream to discriminate between plausible mechanistic hypotheses

-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia