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Melanosomes transfer melanin primarily to the hair cortex, to a lesser extent to the medulla, and only occasionally to the cuticle.7 Unlike epidermal melanocytes, the hair bulb contains approximately 1 melanocyte for every 5 keratinocytes, and hair follicle melanocytes have longer and more numerous dendrites.8 The second melanocyte location within the hair follicle is the bulge area

Nuclear-enriched and m 6 A-modified transcripts are shown as yellow-filled red (upregulated) or blue (downregulated) circles

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Multiple lines of evidence prove that reducing reagents and nonionic detergents in the binding and washing buffers could dramatically reduce the highly nonspecific binding and get purer proteins