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Further research revealed that the overexpression of AURKA mitigates diabetic limb ischemia by enhancing ferroptosis and inhibiting oxidative stress and lipid peroxidation both in vitro and in vivo [188]

Kuleshov MV, Jones MR, Rouillard AD et al (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

NETs can promote apoptosis in cardiomyocytes via the autophagy pathway, and cause swelling of mitochondria in cardiomyocytes, depolarization of mitochondrial membrane potential, and increased production of mitochondrial ROS (153), resulting in an increased susceptibility to AF (152)

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Therapeutic potential and immunomodulatory role of coenzyme Q10 and its analogues in systemic autoimmune diseases

Biotin (1 mM in PBS, sterile filtered) was added to a final concentration of 50 M at the indicated timepoint, and cells were harvested 24 h after transfection