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Description

By depleting GSH, CR increased the expression of Pepck-M, which can alter TCA flux

Raza H, Ahmed I, John A, Sharma AK

All one carbon metabolism (methylation) reactions occur within mitochondria

Yang and Stockwell, 2016)

The authors also found that intestinal epithelial cell-specific Slc39a8 knockout (Slc39a8-IEC KO) mice have markedly decreased Mn levels in the blood and in most organs and develop colitis

Moreover, glutathione fuels the production of cytokines, and it is needed to uphold interferon-gamma production by dendritic cells, which are instrumental in defending against intracellular pathogens that includes mycobacteria