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Vitamin B12 deficiency occurs when there are low levels of Vitamin B12 in your blood

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While ex vivo organ culture uses real human tissue, it cannot fully replicate conditions on a living scalp including skin absorption, blood supply, hormonal influences, and the immune system

Vitamin B12 Regulates Cytokines and Neurotrophic Factors A very new research field has brought to light astonishing new functions of B12 in the nervous system, which go far beyond its role as coenzyme and rather resemble the mode of action of a hormone: vitamin B12 regulates the level of certain neurotrophic factors such as neurotransmitters, growth factors and the so-called cytokines essential messenger substances that all assume a controlling function in numerous bodily processes (32)