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Additional evidence of systemic inflammation effecting the CNS is seen in a mouse model of intraperitoneal LPS injection, which revealed morphological changes in microglia after 3 h, suggestive of an activated state, that persisted up to one week post injection (Yang et al., 2013)

Leaky gut involves damage to the bodys intestinal lining and causes tight junction malfunctions, which allow substances like bacteria and food particles that are not intended to go through your gut wall, to pass through

doi: 10.1016/j.copbio.2012.08.005 154 LeighS.-J.UhligF.WilmesL.Sanchez-DiazP.GheorgheC

179 Lee MR, Rohn MCH, Tanda G, Leggio L

R Mildly elevated bilirubin actually has antioxidant benefits (bilirubin is a potent free radical scavenger), and Gilbert syndrome has been associated with reduced cardiovascular disease risk

Notably, extracellular region emerged as the most abundant term among the CCs, while peptidase activity, acting on L-amino acid peptides, endopeptidase inhibitor activity, and endopeptidase activity ranked among the top three terms within the MF category